Welcome to 301 S Palmetto Avenue - historic charm meets modern living in this beautifully renovated 4-bedroom, 2.5-bathroom, 2-story home, ideally located at the place where two historic districts meet: the Sanford Residential Historic District and the Sanford Commercial Historic District - and this property truly represents the best of both worlds. Multiple zoning uses offer endless possibilities for your lifestyle or business dreams. Whether you envision it as your dream home or a thriving business, this property fits the bill. Consider transforming it into a charming bed and breakfast, a trendy restaurant, a boutique, professional office. This home is currently operating as a turn-key short term rental and is being sold fully furnished. Nestled right in the middle of Historic Downtown Sanford and literally steps away from all the shops, dining, and nightlife that make this location so desirable. This home recently received a complete renovation, preserving its historic character while updating to today's standard of living. Enjoy peace of mind with a brand new roof and other updated mechanicals. A spacious DOWNSTAIRS PRIMARY SUITE provides convenience and privacy, perfect for accommodating guests or offering a retreat-like experience. The downstairs living spaces flow seamlessly, ideal for entertaining. A modern, fully equipped kitchen with stainless steel appliances , resilient LVP flooring throughout and upstairs, spacious bedrooms with ample closet space and an additional full bathroom (all bathrooms have been updated with stylish fixtures and finishes!) The beautiful original windows adding warmth, light and elegance to every room. A charming front porch perfect for relaxing and enjoying the vibrant downtown atmosphere and a private backyard offering a peaceful oasis amidst the bustling city. Whether you're looking for a unique residential home with historic flair or an exceptional commercial property in a prime location, this downtown gem offers the best of both worlds. Don't miss this rare opportunity to own a piece of history with unlimited potential!